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Institute of Chemical Technology Prague

Masaryk University

Universidad de Chile

Norwegian University of Science and Technology

RWTH Aachen University

Indexing Adaptive Similarity

Research area: 
Multimedia

When determining content-based similarity between two multimedia objects, the distance is evaluated on feature representations which aggregate the inherent properties of the multimedia objects. The conventional feature representations aggregate and store these properties in feature histograms, which can be compared by vectorial distances. Recent feature representations adaptively aggregate and store individual object properties in more flexible feature signatures, which can be compared by adaptive similarity measures, such as the quadratic form distance or the Earth mover's distance.

Multimedia Exploration

Research area: 
Multimedia

While traditional content-based retrieval approaches provide query-driven access under the assumption that the users' needs are clearly specified, modern content-based exploration approaches support users in browsing and navigating through multimedia databases when imprecise or even no retrieval intent is given. By means of interactive graphical user interfaces, exploration approaches offer a convenient and intuitive access to unknown multimedia databases which becomes even more important with the arrival of powerful mobile devices, such as the iPad and iPhone.

Tandem Mass Spectrometry, Protein Sequences Identification

Research area: 
Bioinformatics & Cheminformatics

Proteins, organic molecules made of amino acids, are essential for construction of cells and for their proper function. The mass spectrometry is a widely used method for determining protein sequences from a biological (wet) sample. The sequences are not determined directly, but they must be interpreted from the mass spectra, which is the output of the mass spectrometer

Protein Structure Similarity

Research area: 
Bioinformatics & Cheminformatics
Proteins perform many different biological functions and so ensure most of the vital processes in the living organisms. Proteins can fold into various 3D structures and this is the reason for their huge functional diversity. Better understanding of protein function can result in more effective drugs or various industrial products (e.g., laundry detergent containing enzymes).
 

RNA Function Elucidation

Research area: 
Bioinformatics & Cheminformatics
It was believed for many years that the only function of RNA is to transfer genetic information to ribosomes where it is translated to proteins. However, it has been revealed recently that ribosomes themselves are formed by RNA molecules having catalytic function. Therefore, RNA is not only a mere transportation medium but it can be involved in many enzymatic processes in living organism. It has also been recently shown that RNA can act as a gene regulator, thus influencing whether given gene will be translated and in what amount. Clearly, deep understanding of the mechanisms behind RNA function can have a great impact on the drug discovery related areas.

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